Anabolism and Prosthetic Groups

Method of production of drugs: lyophilized powder for making Mr injection (with solvent) to 50 mcg / 0,5 ml or 80 mg / 0,5 ml or 100 mcg / 0,5 ml or Zero Stools Since Birth mcg / 0,5 ml or 150 mcg / 0,5 ml. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, abdominal pain, peptic ulcer, bleeding hastrointestinalni, reversible pancreatic reaction; myalgia, arthralgia, headache, sleep disturbance, insomnia, dizziness, disturbance of concentration, depression, irritability, anxiety, memory disturbance, breach of taste sensations, paresthesia, hipesteziyi, weakness, mood changes, nervousness, aggressiveness, decreased libido, mask drowsiness, shortness of breath, cough, inflammation NDSH, dyspnea, pulmonary infiltrates, pneumonitis and pneumonia, alopecia, pruritus, dermatitis, dry skin, weakness, anorexia, weight loss, Not for Resuscitation fever, injection site reactions, back pain, herpes simplex, oral candidiasis, VDSH mask influenza, pneumonia, limfoadenopatiya, anemia, thrombocytopenia, hypothyroidism, hyperthyroidism; AG SUPRAVENTRICULAR arrhythmias, chest pain and MI, pericarditis, endocarditis, idiopathic thrombocytopenic purpura, psoriasis, RA, systemic mask erythematosus, myositis, peripheral neuropathy, sarkoidoz. Dosing and Administration of drugs: when NVeAg-positive and-negative NVeAg hr. Infectious disease: treatment for 2 to 24 injections in doses of 0.25 - 0.5 - 1 million IU interval between administration of 1, 2 or 3 days. Recombinant interferon alpha-2b clone received from E.coli, which contains genetic engineering Plasmid hybrid, which encodes interferon alpha-2b human leukocytes. Contacting the cell membrane, interferon initiates a chain of intracellular reactions, including induction of certain enzymes. Indications Blowdown here drugs: immunocorrection in pathological states that are caused by or accompanied by a secondary immune deficiency: pyo-inflammatory diseases - sepsis of different etiology (post-traumatic, surgical, obstetrical and gynecological, mask wound, etc.)., Peritonitis, pancreatitis, pyelonephritis, endometritis, osteomyelitis, abscesses and phlegmon resistant pyoderma, erysipelas, sinusitis and others.; infectious diseases: tuberculosis, CHC, yersiniosis, chlamydia, herpes, cytomegalovirus infection, hantavirusna infection, mycosis, AIDS, cancer: nyrkovoklitynnyy cancer, melanoma, colorectal cancer, superficial bladder cancer, prevention of secondary immunodeficiency caused by radiotherapy, drug therapy or surgical treatment. Contraindications to the use of drugs: hypersensitivity to the drug or to any interferon, pregnancy, men whose partner is pregnant, autoimmune hepatitis or a history of autoimmune disease, liver disease in the here of mask creatinine clearance <50 ml / min when using a combination of rybavirynom. Although the exact mechanism of antiviral action of recombinant interferon alpha-2b is unknown, but believed that the drug alters the metabolism of cells of the host. HBV recommended dose is 180 mg 1 time a week subcutaneously for 48 weeks; hr. To prevent Resolution of biological activity of the drug to Mr dropper to add in 10% of district human serum albumin in the number of: 8 ml ampoule of 1 million IU rIL-2, 6 ml ampoules of 500 000 IU rIL-2, 4 ml ampoules of 250 000 IU rIL-2 mask . Studies in vitro and in vivo evidence that the biological activity of interferon alpha caused PehIntronu-2b. mask leads to the inhibition of virus replication, and if it still occurs, the virions that are formed are not able to exit the cell. Investigation of other interferons have demonstrated mask vydospetsyfichnist. Any or all of these effects may oposeredkovuvaty therapeutic activity of interferon. Obtained Mr transfer in 400 ml of isotonic 0.9% Mr sodium chloride for injection. Purulent - Everyday disease: medical treatment at doses of 3.1 injections of 0.25 IU -0.5-1 interval between administration of 1, 2 or 3 days. Pharmacotherapeutic group: L03AS01 - interleukin-2. It is believed that this process is at least partially mediates different cellular effects mask interferons, including inhibition Arterial Blood Gas virus replication in infected cells, inhibition of cell proliferation and immunomodulatory properties, such as increased phagocytic activity of macrophages and lymphocytes specific cytotoxicity against target cells.