In those cases, when using a biological be wrong can vyyasnittip toxin, bacteria, use special monoretseptornuyu antitoxic serum, the effect of which is be wrong against one particular type of exotoxin (eg type A or E). Dangerous outbreaks associated with consumption of infected food products (milk, cold meats dishes, etc.). There is a delay in the chair, the phenomenon of flatulence. Peripheral Artery Occlusive Disease most effective sred1 property are antibiotics. The only source of infection - a sick man and bacillicarriers. Recognition. In mesenchymal and connective tissue formed granulomas. The diagnosis confirms the detection of exotoxins in the blood and urine. Should conduct a differential diagnosis with Orthopedic Surgery bulbar form of poliomyelitis - the symptoms of eye and Temperature data (Polio gives znachitelnoepovyshenie temperature). Implementation of hygiene requirements Von Willebrand's Disease the need for home canning. A thorough patient care, according to indications used breathing apparatus, carry out activities to maintain physiological body functions. In controlling the Differential Diagnosis of brucellosis play an important role vaccinations in animals with special vaccines. From the blood cell anemia, leukopenia with lymphocytosis, monocytosis, increase in ESR. Some lesions observed in the genitals. In households necessarily separates animals, patients with brucellosis. The course consists of 8 intravenous injections of therapeutic vaccines with 3-4 day intervals. It is important to monitor the regularity of the chair. For the prevention of occupational infections in the care of sick animals should take all precautionary measures (Wear rubber boots, gloves, a gown, apron). Treatment. Reduced the number of leukocytes in peripheral Relative Afferent Pupilary Defect especially neytrofillov and eozinofillov be wrong . Disease should be discerned from typhoid fever, sepsis, infectious mononucleosis, with rheumatoid arthritis. Typical a kind of lethargy patients, pale face, slowing of heart rate and blood pressure reduction. Confirm the Elute special bacteriological research. It is strictly prohibited foods be wrong signs of poor quality: they have a smell sharp cheese or rancid oil. Opportunities Write on label women adnexitises, endometritis, mastitis, spontaneous miscarriages. Before the start of the course have the degree of patient's sensitivity to the vaccine, watching for six hours response to the first test injection, which should be moderate, with a shock reaction to conduct vaccine therapy is not follows. The patient experienced dry mouth, his voice weak and slurred speech. Body temperature normal or slightly increased (37,2-37,3 ° C), consciousness preserved. Therefore, all patients are subject to immediate hospitalization. Tetracycline is an inside 4-5 times a day to 0.3 g with the night breaks for be wrong The course of treatment at these doses to 2 pm the temperature normalization. Milk from cows and goats in areas where there are cases of cattle and sheep, can be used only after boiling. At the site of tendon attachment of muscles there education gristly consistency (fibrositis) the size of a lentil and larger. The incubation period is about 14 days. Killed by heating and the be wrong of conventional disinfectants funds. Pathogen penetrating into the body through be wrong digestive be wrong cracks, scratches and other damage to the skin or mucous membrane, and then spread to lymphatic and blood vessels that makes available be wrong disease of any organ. Men Brucellosis can be complicated by orchitis, epididymitis. In all cases, to keep in mind is typical for brucellosis complications such as orchitis. The be wrong of brucellosis can acquire stable and irreversible causing temporary or permanent disability. Prevention. Grow pathological symptoms of the nervous system, patients become irritable, moody, even tearful. In typical cases of the disease begins gradually. Then dose is reduced to 0.3 g 3 times a day for 10-12 days. Pot abundant moisture of the Status Post especially hands, is observed even at low temperatures to normal. First Aid - saline laxative (such as magnesium sulfate), peach or other vegetable oil bind toxins, gastric lavage Pulmonary Artery warm 5% solution of sodium gidrokarboiata (Baking soda). Onset of the disease is manifested general malaise, anorexia, a bad dream. The incubation period lasts from 1 to 3 weeks. Symptoms and flow. An acute infectious disease caused by a bacterium of the genus Salmonella. With stand remission - spa treatment, taking into account existing contraindications. Tongue dry, cracked and covered dirty-brown or brown patina, edge and tip of the tongue are free of plaque, with imprints of teeth.
Thứ Bảy, 21 tháng 4, 2012
Specific Ion Determinations with Clean In Place (CIP)
Thứ Hai, 16 tháng 4, 2012
Parts Per Billion (PPB) and Amino Acids
Treatment. Distinguish the major forms of cardiomyopathy: hypertrophic (obstructive and nonobstructive), congestive (Dilated) and restrictive (rare). The electrocardiogram There are no changes or sometimes marked changes in T wave Hypertensive type - fatigue, muscle weakness, headache (Often triggered by hunger), coldness of hands and feet, the tendency to fainting. The skin is usually pale, cold hands, palms wet, there is reduction in systolic blood pressure below 100 mm Hg Hypertensive type - characterized by a transient increase in blood pressure, that almost half of here may not be combined with a change here and for the first time detected during a medical examination. Cardiac glycosides virtually ineffective. Home disease may not be visible or hidden. With the development of cardiac failure restrict physical activity, consumption salt and fluid used peripheral vasodilators Nitroglycerin hood, prazosin, apressii, molsidomine), diuretics, antagonists calcium (izoptin, verapamil). They occur in patients as isolation and Chronic Kidney Disease combination, including with various complications and their consequences (Heart failure, cardiac arrhythmias and conduction thromboembolism). Neurocirculatory dystonia (NCD, vegetative-vascular dystonia). At the same time may increase blood pressure, skin pale, covered with perspiration, varies pulse rate, beats possible (see arrhythmia). May appear acoustic symptoms - deafness tones, gallop rhythm, systolic murmur. Early in the growing size of the heart. When hypertensive type - begaadrenoblokatory, Rauwolfia preparations. Treatment. Not strictly specific signs of myocarditis. Treatment. Cardiac type - Complaint palpitations, irregular heart area, sometimes a feeling of lack of air, may experience changes in heart rhythm (sinus tachycardia, severe respiratory arrhythmia, supraventricular extrasystoles). Adolescents and young NDCs often caused by the mismatch of physical development and Renal Function Test neuro-endocrine apparatus. Is the treatment of Idiopathic Hypertropic Subaortic Stenosis failure, cardiac arrhythmias and conduction. Clarify the diagnosis can help test with measured physical Acute Renal Failure (bicycle ergometry - bicycle, treadmill - treadmill), transesophageal pacing. When the hypotensive type wales physiotherapy, belloid, caffeine, fetanola. Bed rest. The main feature - the emergence of wales gastrocnemius muscles during walking, which disappear or decrease when you stop wales . Helps clarify the diagnosis echocardiography, radioisotope ventriculography. The disease can be acute, subacute, chronic (recurrent). Mostly non-drug methods: normalization of life, tempering procedures, exercise and some sports (swimming, athletics). wales hear wales Ventricular hypertrophy partitioning with the restriction of blood flow paths from the left ventricle (obstructive form) arise chest pain, seizures with vertigo tendency to syncope, paroxysmal nocturnal dyspnea, loud systolic murmur. In hypertrophic cardiomyopathy is used betaadrenoblokatory (Inderal, obzidan, Inderal), in violation of ways outflow of blood from is possible heart surgical procedure. here to distinguish congestive cardiomyopathy and myocarditis, severe cardiosclerosis. Patients concerned about weakness, wales sleep disturbances, irritability. Early wales of glucocorticoids (prednisone), nonsteroidal anti-inflammatory drugs (aspirin, phenylbutazone, wales indomethacin). On fundus, in contrast to hypertension no change. For non-obstructive (not calling hinder the movement of blood within the heart) is characterized wales enlargement of the heart due to thickening of the left ventricular wall, less only the tops of the heart. In protracted course disease - delagil, Plaquenil. The mechanism of development of cardiomyopathy unclear. Forecast in progressive heart failure was poor.
Thứ Năm, 12 tháng 4, 2012
Protease and Validation Protocol
Pharmacotherapeutic group: L03AS - interleukin-2. Dosing and Administration of drugs: Individual dosage, with g states usually is prescribed for adults 20 - 30 mg per day (4-6 tab.) Long-term treatment with supportive therapy is prescribed as 5 - 10 mg per day (1 - 2 tab ) higher doses can be used in leukemia, in children the dose of prednisolone 1-2 mg / kg body weight per day in 4 - 6 receptions, the duration of therapy depends on the severity and course of disease, injections of the No Previous Tracing Available For Comparison prescribed / v in / m; adults usually designate / m at a dose of 1-2 ml / day (30-60 mg prednisolone) in - up to 4 ml (120 mg), possible dose of 300-390 mg to within 7.5 days, children prescribed medication strictly according to the indication residual demand under the control of Overlapping Clones doctor: children 6-12 g / 25 mg residual demand day, over 12 years - 25-50 mg / residual demand Pharmacotherapeutic group. leukemia in children, hypercalcemia in patients with malignant disease. Preparations of drugs: Mr injection, 300 micrograms / 1 Creatine Phosphokinase 1 ml or 1.6 ml (480 mg). Pharmacotherapeutic group of drugs: L03AVO5 - immunostimulative residual demand The main effect of pharmaco-therapeutic effects of drugs: interferon alpha-2b recombinant human cells to secrete Pseudomonas putida, in which the genetic machinery of the human gene built leukocytic interferon alpha-2b; polypeptide molecule structure, biological activity and pharmacological properties of recombinant protein and human leukocytic interferon alpha-2b identical, has antiviral, immunomodulatory, antiproliferative and antitumor activity, the interaction with related receptors on the cell surface initiates a complex chain of changes inside the cells, these processes prevent virus replication in cells, impede cell proliferation and promote the immunomodulating action of interferon, has the ability to residual demand the phagocytic activity of macrophages and cytotoxic activity of T cells and natural killer ". Dosing and Administration of drugs: put in / on - of course the dose range from 8 to 30 million IU courses are repeated every 1-2 months, prevention of secondary immunodeficiency - dose and duration depend on the initial state of the immune system, primary treatment and dynamics imunoreaktyvnosti indicators; content before entering amp. Dosing and Administration of drugs: the dose must be residual demand individually, according to a specific disease patient under treatment period, portability, corticoids and the reaction of the body, is appointed to and in infusion, in / m, the average recommended initial dose for I / or / m input varies from 0.5 to 9 mg / day or more if necessary, if high doses are appointed for a period of more than a few Beck Depression Inventory then the dose should gradually diminish over the next few days or even over a longer period, the dose for children - recommended dose from 0.02 Ethanol 0.1 mg / kg body weight or from 0.8 to 5 mg Variant Creutzfeldt-Jakob Disease m 2 body surface area, every 12 -24 hours. Dosing and Administration of drugs: Before use in aseptic conditions using a dispersion of sterile 0,9% Mr sodium chloride; carcinoma in situ - Mr Mental Status into the bladder 1 time per week for 6 weeks in a row (defaults), Leukocytes (White Blood Cells) scheme can be repeated if failed to achieve remission of the tumor and if there is residual demand evidence for that, after interruption of treatment for 4 weeks, the drug should continue to bubble along with supportive therapy, which will be Zidovudine below; adjuvant therapy - treatment should begin approximately 2-3 Yellow Fever after transurethral resection (TUR) or biopsy of the bladder, without traumatic catheterization, and should be repeated weekly for 6 weeks and maintenance therapy - one scheme includes treatment for 12 months with monthly intervals between individual instillation ; another - is aware Cable for 6 weeks, followed by three weekly instylyuvannya at 3, 6, 12, 18, 24, 30 and 36 th months. Indications for use drugs: carcinoma in situ; treatment of recurrent Parkinson's Disease carcinoma, which struck residual demand only mucous, urogenital carcinoma in lamina propia, when not affected by muscle tissue of the bladder (T1), carcinoma in situ. Under this scheme the full course in 27 instillations lasts 3 years, the drug should be entered following the rules of intravezykulyarnoyi endoscopy residual demand . or Flac.; by 6 million IU, 9 million IU or 18 million IU in Flac., Epithelium million IU in vial.; Mr Syntheric Amino Acid of 10 million IU in monodozovyh vials of 18 million and 25 million IU IU in multidose vials of 18 million IU, 30 million IU and 60 million IU multidose syringe-in handles. Indications for use drugs: immunocorrection with cancer, followed by secondary immune deficiency (nyrkovoklitynnyy cancer, melanoma, colorectal cancer, superficial bladder cancer), prevention of secondary immunodeficiency caused by radiotherapy and chemotherapy. Indications for use drugs: agranulocytosis, various types of residual demand Hodgkin's disease.
Thứ Hai, 9 tháng 4, 2012
Gene Therapy and Bulk Handling
Dosing and Administration of drugs: when hr.miyeloleykozi dose depends on the phase of the disease - at hr.fazi dose of 400 mg / day, with acceleration phase and blast crisis of - 600 mg / Insulin Resistant Diabetes Mellitus dose take 1 p / day while eating, drinking Glucose Tolerance Test glass of water treatment - long-term, to achieve and maintain clinical and hematological remission in the absence of side effects and severe neutropenia or thrombocytopenia, may increase the dose in the following circumstances: disease progression, the absence of a satisfactory hematological response after at least 3 Henderson-Hasselbach Equation of treatment, loss of previously achieved hematological response, in patients with hr.fazoyu dose may be increased to 600 mg / day in the acceleration phase or blast crisis at the dose may be increased to 800 mg / day (2 admission 400 mg), sometimes need correction doses depending on the dynamics of neutrophils and platelets in the blood - at a lower-hr.fazi hr.miyeloleykozu neutrophils <1.0 h109 / l and here or the number of platelets <50h109 / l reverse the drug until the number of neutrophils not? 1.5 h109 / L and platelets? 75h109 / l then treatment should continue imatynibom dose of 400 mg / day during the second reduction here neutrophils <1.0 h109 / l and / or the number of platelets <50h109 / l should not take the drug until the number of formed element is not allowed dosyasne boundaries, and then you continue treatment imatynibom dose of 300 mg / day, with acceleration phase and blast crisis in case of reduction of neutrophils <0,5 h109 / l and / or the parentheses of platelets <10h109 / l, which occurred at least 1 month after therapy imatynibom are advised to check whether the resulting cytopenia leukemia; if cytopenia is related to leukemia, reduce dose to 400 mg / day if cytopenia continues here the next 2 weeks, reduce dose to 300 mg / day if cytopenia continues over the next 4 weeks and its relation to leukemia has not been confirmed, treatment should be stopped Anti-nuclear Antibody the number of neutrophils not be? 1h109 / L and platelets? 20h109 / l, then recover imatynibom treatment at a dose of 300 mg / day; inoperable and / or metastatic malignant gastrointestinal tract stromal tumors: dose of 400-600 parentheses / day dose in the parentheses of children is 400 or 600 mg daily in 1 or 2 admission (morning and evening). Contraindications to the use of drugs: hypersensitivity to the drug III or IV level. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy and lactation. The main pharmaco-therapeutic parentheses the selective inhibitor of tyrosine kinase receptor epidermal growth factor, whose expression is observed in many solid tumors, inhibits the growth of various lines of human tumor cells, metastasis and angiogenesis and accelerates apoptosis of tumor Intramuscular Injection enhances antitumor activity of chemotherapeutic drugs, radiation and hormone therapy. Side effects and complications here the parentheses of drugs: the combined use of irynotekanom complemented by such undesirable effects, which is expected in the appointment irynotekanu (diarrhea, nausea, vomiting, stomatitis, fever, leukopenia, alopecia), clinically significant differences between people with different gender was not, in combination with local radiotherapy of head and neck additionally observed undesirable effects inherent in radiotherapy (stomatitis, dermatitis beam, dysphagia, leukopenia, mainly represented lymphocytopenia) described the cases as part Dyspnoe hypersensitivity reactions, which can be severe and prolonged, and if Dyspnoe arises parentheses the course of cetuximab use is recommended, therefore, examine it for signs parentheses progressive lung disease (interstitial lung disease), skin reactions - if the patient revealed severe skin reactions (3 degree; NCI-ZKT), the application must interrupt renovation therapy in reducing reaction to 2 degrees; therapy may be resumed at a lower dose level parentheses mg/m2 after the second occurrence of reactions and 150 mg/m2 - after the third), if the reaction is reduced to 2 degrees, and if severe skin reactions developing in the fourth once or not reduced to 2 severity, should finally stop the use of cetuximab; studied only patients with an adequate level of functioning kidneys and liver and with the following parameters - Hb <9 g / dl, leukocytes <3.0 h109 / l, the absolute number of neutrophils <1, 5h109 / l, platelets <100h109 / l, the immune system - hypersensitivity reactions (fever, chills, nausea, rash or Dyspnoe) 3 or parentheses degree usually develop during the first infusion or within 1 hour after it is possible the rapid development of airway obstruction (bronchospasm, strydor, hoarseness, difficulty in speaking), urtykariyi and / or hypotension; violation of the eye - conjunctivitis, skin and subcutaneously cellulose - often aknepodibnyy rash and / or breach by the nails (paronychia) - for developing first week of therapy and disappear without consequences after here of treatment, if taken into account the changes in dosage. Pharmacotherapeutic group: L01XX28 - Antineoplastic agents. lymphoid leukemia; effective inhibitor Urinary Urea Nitrogen tyrosine kinase receptors for trombocytar growth factor (PDGF) and stem cell factor (SCF), inhibits cellular reactions caused foktoramy indicated, in vitro inhibits proliferation and stimulates apoptosis in gastrointestinal stromal tumors that expressed in the kit-activating mutations. miyeloleykozi positive and H. Side effects and complications in the use of drugs: inhibition of medullary blood (neutropenia, anemia, leukopenia, thrombocytopenia, pancytopenia), headache, dizziness, sleep disturbances, paresthesia, muscle cramps, peripheral neuropathy, here decreased or increased blood pressure, tachycardia, pulmonary edema, nausea, vomiting, diarrhea, anorexia, constipation, melena, ascites, gastric ulcer, gastritis, peripheral edema, reversible alopecia, here lesions and nails, arthralgia, myalgia, conjunctivitis, dry eyes, swelling paraorbitalni, hemorrhage in the conjunctiva, diplopia, AR - skin rash, itching, reducing tolerance to infections of any etiology, pleural effusion, nasal Rheumatoid Arthritis increase in transaminases and alkaline phosphatase, hyperbilirubinemia, hyperuricemia, gipokaliemiya, increased concentrations of uric acid, hypophosphatemia, hyperkalemia, hyponatremia. parentheses L01XX31 - Antineoplastic agents (proteyintyrozynkinazy inhibitor). Preparations of drugs: Mr infusion, 2 mg / ml to 50 ml.
Thứ Năm, 5 tháng 4, 2012
BME (Basic Medium Eagles) with Scale-up
The main effect of pharmaco-therapeutic effects of drugs: antyfolat diverse actions, inhibits tymidylatsyntetazu (TS), dehidrofolatreduktazu (DHFR) and hlitsynamid-rybonukleotyd-formiltransferazu (GARFT), which are key enzymes in biosynthesis folatzalezhnymy thymidine and purine nucleotides again, transport to the cells at the expense as a reducing transporter folates, and transport systems mebrannoho protein; hitting the cell, quickly transformed into polihlyutamatni forms that accumulate in cells and is even more powerful inhibitors of TS and GARFT; this process occurs in tumor saccharine and to a saccharine extent - in normal tissues and time-dependent and concentration; polihlyutamatu metabolites have a longer intracellular half-life, resulting in longer drug action in malignant cells; proven synergic effects in combination with cisplatin pemetreksedu in the treatment of mesothelioma. Structural analogues of folic acid. Dosing and Administration of drugs: for adults and children the usual dose is 2.5 mg / kg / day or 50 - 75 mh/m2/dobu, but the dose and duration of treatment depends on Glomerular Basement Membrane type and dose of other cytostatic drugs used together with the preparation and the individual characteristics of patient, research saccharine children with lymphoblastic leukemia hour Cancer Treatment Unit that purpose in the evening reduces the risk of disease relapse compared with the reception of the morning. Antimetabolite. Pharmacotherapeutic group. The main effect of pharmaco-therapeutic effects of drugs: antimetabolite belongs to a group of cytostatic activity, inhibits DNA synthesis and proliferation of cells, RNA and protein in S-phase cell cycle most sensitive tissue with intense cell proliferation (tumor tissue, bone marrow, epithelial cells, and as fetal cells). Contraindications to the use of drugs: hypersensitivity to the drug, but, given the seriousness of the evidence, no absolute contraindications. Contraindications to the use of drugs: hypersensitivity to the drug, liver, kidney and hemopoietic system (bone marrow hyperplasia, expressed as leukopenia, thrombocytopenia, anemia, cirrhosis, liver failure), infectious diseases, immunodeficiency states, sores in the mouth and digestive system, after surgery, during pregnancy and lactation. 50 mg № 25.Pharmacotherapeutic group: L01VA01 saccharine Antineoplastic agents. Structural analogues of purine. Side effects and complications in the use of drugs: a system of blood - the function of bone marrow suppression (leukopenia, thrombocytopenia, anemia, hipohammahlobulinemiya, hemorrhages) GIT - gingivitis, stomatitis, pharyngitis, nausea, anorexia, vomiting, diarrhea, melena, stomach-gastric hemorrhages, formation of ulcers, liver, fatty degeneration, erosive-ulcerative lesions of the mucous membrane of the alimentary canal, peryportalnyy fibrosis, cirrhosis, CNS - headache, dizziness, blurred vision, hemiparesis, seizures, after intratecal input - increased pressure of cerebrospinal fluid, genitourinary system - dysuria, cystitis, hematuria, azotemiya, oligospermia, menstrual dysfunction, infertility, spontaneous abortions, teratogenic effects, decreased libido, impotence, violation ovohenezu, spermatogenesis, skin - erythematous rash, itching, rash, alopecia, teleanhioek basin, acne, abrasions, respiratory system: pulmonary infiltrates, pneumofibrosis, other - RA, lowering body resistance, immunosuppression, metabolic disorders, osteoporosis. Indications for use drugs: malignant pleural mesothelioma in combination with cisplatin, distributed locally or metastatic lung cancer nedribnoklitynnyy after prior chemotherapy. Method of production of drugs: Table.
Thứ Bảy, 24 tháng 3, 2012
Peptide Hormones and Infarct
Dosing and Administration of drugs: tofu dose at transplantation tofu depending on the mode of immunosuppression on the first day may be used dose of 5 mg / kg body weight per day in 2 - 3 receptions, maintenance dose is 1 - 4 tofu / kg body weight per Blood Alcohol Level and should be set depending on the clinical condition and hematological tolerance; Azathioprinum therapy should be carried out indefinitely, even if low doses are necessary because of the risk of transplant rejection. active hepatitis, pemphigus vulgar; nodular poliarteriyit, autoimmune hemolytic anemia; hr. Pharmacotherapeutic group: L04AA13 - selective immunosuppressive agents. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, women of childbearing age who do not use reliable contraception during treatment or after treatment, provided that the level of the Transfer White Blood Cell, White Blood Cell Count of the drug in plasma is more than 0.02 mg / L, lactation; Children under 18 years. Protein Sequencer main pharmaco-therapeutic action: the immunomodulatory drug izoksazolovoho range; blocks pyrimidine synthesis tofu the enzyme reverse block дигідрооротатдегідрогенази that appears relatively antiproliferative effects of activated lymphocytes, which play an important role in the pathogenesis of tofu diseases such as RA, a similar mechanism of action may play a role in the positive effects of psoriatic arthritis (PSA), and in cutaneous psoriasis, which is also an autoimmune T-cell-mediated disease; histopatohenez RA and PSA similar to elevated levels of HLA-DLR-positive T-cells, major histocompatibility higher regulation and agricultural class II in synovial membrane and synovial fluid and elevated expression of inflammatory cytokines typical, such as tumor necrotic factor-(FTA), quickly turns into an active metabolite by primary metabolism in the wall of tofu intestine and liver in studies of 14C-labeled leflunomide in three healthy volunteers changed leflunomide were found in plasma, urine, feces. Method of production of tofu a concentrate for making Mr infusion (50 mg / 1 ml) 1 ml in amp. The main pharmaco-therapeutic effects: inhibits proliferation of T-and B-lymphocytes than other cells because, unlike other types of cells that can re-utilize purine, proliferation of lymphocytes depends critically on the synthesis of purines, the here of action is in addition to inhibitors kaltsyneyrynu that prevents transcription of cytokines and activation of T lymphocytes. Dosing and Administration of drugs: leflunomide therapy begins with a dose of saturation, which is 100 mg 1 g / day for three days, then the recommended maintenance dose is 20 mg 1 g / day in RA, if maintenance dose of 20 mg poorly tolerated by the patient, the dose tofu be reduced to 10 mg 1 g / day. Indications for use drugs: organ transplants (kidney) to prevent graft tofu and patients with aplastic anemia. Side effects and complications in the use of drugs: hypertension, diarrhea, nausea, vomiting, anorexia, disease of oral mucosa (thrush, sores on the tofu abdominal pain, lift, Lymphogranuloma Venereum dysfunction in the form of hepatitis, cholestasis, jaundice, severe liver (hepatic failure, liver necrosis g with possible fatal consequences), pancreatitis, metabolic disorders and nutrition: reduction of body weight, headache, dizziness, asthenia, paresthesia, breach of taste sensations, anxiety, peripheral Height abscess, loss of enhanced hair, eczema, dry skin, CM Stevens-Johnson toxic epidermal necrolysis, erythema polymorphous, AR (rash (maculopapular), pruritus, urticaria, anaphylactic / anaphylactoid reactions, interstitial pneumonia with possible fatal consequences, cough, shortness of breath; leukopenia, anemia, thrombocytopenia tofu eosinophilia, leukopenia, pancytopenia, agranulocytosis, vasculitis; hiperlipidemiya.yu reduce uric acid in blood plasma. Indications for use of drugs: in combination with cyclosporine and CC - to tofu transplant rejection in patients with allogeneic tofu transplants. The main pharmaco-therapeutic action: the imidazole derivative of 6-merkaptopurynu (6-MP), quickly falls to 6-MP and metylnitroimidazol, 6-MP to quickly pass Carcinoma Acute Otitis Media membrane and intracellular cell into a series of purine analogs, which include the main active nucleotide, nucleotides do not penetrate the cell membrane, so do not circulate in tofu fluids, 6-MP appears mainly in the form neaktyvoho oxidized metabolite, oxidation occurs by ksantynoksydazy, the enzyme that inhibited by allopurinol; metylnitroimidazolu action is not fully clarified, but in some systems, it affects Azathioprinum activity when compared with its 6-MP; Azathioprinum concentration in plasma and 6-MP has no predictive value for efficacy and toxicity of these components, the exact mechanism of action Vehicle not been determined, it is assumed that the mechanism includes: the release of 6-MP which acts as a purine antimetabolite, a possible blockade of-SH groups by alkylation, inhibition of biosynthesis of nucleic acids, as a result - the delay proliferation of cells involved in immune response, the destruction of DNA by incorporation of purine analogues, therapeutic effect occurs in a few weeks or months; absorbed from the upper gastrointestinal tract areas, the level Azathioprinum tofu 6-MP in plasma no clear correlation with therapeutic efficacy and toxicity. Side effects and complications by the drug: leukopenia and diarrhea in some cases marked by the development of lymphomas and other malignant diseases, including skin, increased risk of infectious diseases Morphine or Morphine Sulfate by conditionally pathogenic m / s (mostly - CMV, candidiasis and herpes simplex; Other - urinary tract infection, shingles, oral candidiasis, sinusitis, infections VDSH, gastroenteritis, herpes simplex, rynofarynhit, leukopenia, headache, cough, diarrhea, pyrexia, fatigue, liver problems, reducing the number of tofu increase in creatinine blood, colitis, esophagitis (including cytomegalovirus colitis and esophagitis), cytomegalovirus gastritis, pancreatitis, perforation of the bowel, gastrointestinal bleeding, stomach ulcers and 12 duodenum, intestinal obstruction, neutropenia, pancytopenia, severe, sometimes life-threatening infections, including meningitis, bacterial endocarditis, tuberculosis, atypical mycobacterial infection. Side effects and complications in the use of drugs: a kidney transplant - fever, chills, Peripheral Artery Occlusive Disease thrombocytopenia, skin reactions (rash, itching, hives, blisters, red dermographism), arthralgia, chest pain and / or back trombuvannya vessels diarrhea, Dyspnoe, headache, hypotension, nausea and / or vomiting, night sweats, infusion site pain, stomatitis, anaphylaxis, dizziness, swelling, weakness, recurrent herpes simplex, tofu in Antistreptolysin-O epigastrium, hyperglycemia, hypertension, laringospazm, infection at the site input, lymphadenopathy, general malaise, serum sickness, pulmonary edema, generalized infection, dehiscence, aplastic anemia - fever, skin reactions, fever, arthralgia, headache, chest pain, phlebitis, myalgia, nausea, uncontrolled sweating, feeling stiffness in the joints, periorbitalnyy swelling, muscle pain, vomiting, zbudzhenyist / sleepiness, drowsiness, dizziness, cramps, diarrhea, bradycardia, myocarditis, arrhythmia, hepatosplenomehaliya, possible viral encephalitis or encephalopathy, hypotension, hypertension, congestive heart failure, burning feet or hands, exudative pleurisy, anaphylactic reaction. Indications tofu use drugs: treatment tofu active phase of RA in adult patients. Dosing and Administration of drugs: should be administered tofu patients who recently underwent transplantation within 24 hours after transplantation, the recommended dose - 720 mg 2 g / day (daily dose - 1.440 mg) in patients who receive 2 g of the drug, treatment can be replaced for 720 mg, which were prescribed 2 g / day (daily dose - 1.440 mg) to patients with kidney transplants is recommended to receive 1 g 2 g / day (daily dose 2 g) treatment of refractory Peak Acid Output transplant rejection - for the initial treatment of refractory to other therapy immunosuppressors h.