First Pregnancy and Right Lower Extremity

Used primarily for sleep disorders. Carbamazepine (tegretol, finlepsin) - Na + channel blocker. Partial seizures are associated with the appearance of individual foci of excitation in the motor or sensorimotor cortex. Distinguish between partial (focal, focal) seizures and generalized seizures. Barbiturates significantly disturb the structure of sleep: shortened periods of rapid (REM) sleep (REMfazy). An acute barbiturate is manifested coma, respiratory depression. The mechanism of action of phenobarbital is associated with potentiation of GABA (increases sensitivity GAMKAretseptorov) and with a direct inhibitory effect on the permeability of cell piton Side effects of phenobarbital: a sedative effect, somnolence, nystagmus, ataxia, skin rash. When constant use in piton doses prevents the emergence of Hemoglobin A seizures, without causing a hypnotic action. In connection with the blockade of Na + channels cardiomyocytes Phenytoin has piton effects. Phenytoin has teratogenic properties. Specific antagonist of barbiturates does not exist. Side effects of carbamazepine: nausea, headache, diplopia, ataxia, anemia, leukopenia (agranulocytosis possible). Side effects: sedation, ataxia, tremor, nausea, pain in the stomach, liver function abnormalities, thrombocytopenia, neutropenia, alopecia piton . Phenobarbital (Luminal) - one of the first anti-epileptic drugs. Side effects of phenytoin: headache, nausea, nystagmus, diplopia, ataxia, tremor, skin rash, itching, gingival hyperplasia, hirsutism, possibly osteomalacia, megaloblastic anemia. Phenytoin (diphenine) is effective in partial piton tonikoklonicheskih cramps (but not piton Usually phenytoin appointed interior to Supraventricular Tachycardia seizures. The best method is hemosorbtion. To suppress the excitatory processes used drugs substances that block № + channels (phenytoin, carbamazepine), Ca2 + channels (Ethosuximidum), reduce the release of excitatory amino acids (lamotrigine). Generalized seizures may occur in the form of tonikoklonicheskih cramps, absence seizures or myoclonic seizures. Phenobarbital piton acts more slowly and at length - about 8 hours, has a pronounced after-effect (drowsiness). The mechanism of action of phenytoin is associated with its the ability to block Na + channels (phenytoin slows the recovery of Na + channels after inactivation). To prevent tonikoklonicheskih cramps used phenytoin, phenobarbital, carbamazepine, valproate, primidone, and lamotrigine. Today time as a hypnotic is seldom applied. With systematic practice of barbiturates them develop physical drug dependence.